The role of n plant glycosylation in Act d 2 allergenicity
نویسندگان
چکیده
Results N-glycan and protein fractions were recognized by specific IgE of kiwi-allergic patients. By contrast, the sugar moiety showed a reduced capacity to activate basophils and T cells, but not dentritic cells derived of patient’s monocytes. In this sense, the proinflammatory cytokine production, measured as IL6 and IL10, was increased by the incubation of dendritic cells with the sugar moiety. Conclusions The sugar moiety plays a significant role in sensitization, inducing the activation of antigen presenting cells. Nevertheless, the protein fraction is the responsible for the allergic reactions.
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2014